Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction.

نویسندگان

  • Paolo Spallarossa
  • Marco Guerrini
  • Eleonora Arboscello
  • Vera Sicbaldi
چکیده

Enalapril and Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients With Malignant Hemopathies The OVERCOME Trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies) Xavier Bosch, MD, PHD,*y Montserrat Rovira, MD, PHD,yz Marta Sitges, MD, PHD,*y Ariadna Domènech, RN,z José T. Ortiz-Pérez, MD, PHD,*y Teresa M. de Caralt, MD, PHD,x Manuel Morales-Ruiz, PHD,yk Rosario J. Perea, MD, PHD,x Mariano Monzó, MD, PHD,y{ Jordi Esteve, MD, PHDyz

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منابع مشابه

Enalapril and Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients With Malignant Hemopathies

Enalapril and Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients With Malignant Hemopathies The OVERCOME Trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies) Xavier Bosch, MD, PHD,*y Montserrat Rovira, MD, PHD,yz Marta Sitges, MD, P...

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The Effect of Enalapril and Carvedilol on Left Ventricular Dysfunction in Middle Childhood and Adolescent Patients With Muscular Dystrophy

BACKGROUND AND OBJECTIVES In Duchenne and Becker muscular dystrophies, cardiac function deteriorates with time resulting in heart failure which is often fatal. We prospectively evaluated the effect of enalapril and carvedilol on left ventricular (LV) dysfunction in middle childhood and adolescent patients with muscular dystrophy. SUBJECTS AND METHODS Twenty-three patients with LV dysfunction ...

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Letter by Hammoud et al regarding article "Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition".

BACKGROUND An increase in troponin I soon after high-dose chemotherapy (HDC) is a strong predictor of poor cardiological outcome in cancer patients. This finding has important clinical implications and provides a rationale for the development of prophylactic strategies for preventing cardiotoxicity. Angiotensin-converting enzyme inhibitors slow the progression of left ventricular dysfunction in...

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Prevention of High-Dose Chemotherapy–Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition

Background—An increase in troponin I soon after high-dose chemotherapy (HDC) is a strong predictor of poor cardiological outcome in cancer patients. This finding has important clinical implications and provides a rationale for the development of prophylactic strategies for preventing cardiotoxicity. Angiotensin-converting enzyme inhibitors slow the progression of left ventricular dysfunction in...

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Protective effect of carvedilol on adriamycin-induced left ventricular dysfunction in children with acute lymphoblastic leukemia.

BACKGROUND Adriamycin (ADR) is a potent chemotherapeutic agent widely used in the treatment of childhood acute lymphoblastic leukemia (ALL); its clinical use is limited owing to its marked cardiotoxicity. The present study investigated the possible protective role of carvedilol on ADR-induced left ventricular dysfunction in children with ALL. METHODS AND RESULTS Fifty children with newly diag...

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عنوان ژورنال:
  • Journal of the American College of Cardiology

دوره 62 25  شماره 

صفحات  -

تاریخ انتشار 2013